<turbo-stream action="append" target="audio_clips_list"><template>
    <hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8887809-act-brief-real-world-data-access-expansion-esource-implementation-at-scale-and-fda-regulatory"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Real-World Data Access Expansion, eSource Implementation at Scale, and FDA Regulatory Setback for Oncolytic Therapy
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we examine Thermo Fisher&#39;s expanded real-world data access through HealthVerity, how FHIR-based standards are finally enabling scalable eSource implementation, and FDA&#39;s second complete response letter for Replimune&#39;s oncolytic immunotherapy.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
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2m
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<span><span class="js-time" data-epochtime="1776160800" data-format="short_date">Apr 14</span></span>
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<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
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</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8886972-act-brief-clinical-trial-trends-and-2026-outlook-ai-agents-and-workforce-transformation-and-de"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Clinical Trial Trends and 2026 Outlook, AI Agents and Workforce Transformation, and Degrader-Antibody Conjugate Partnership
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore industry perspectives on operational and methodological shifts defining 2026, how agentic AI will augment clinical trial roles over the next two years, and Roche&#39;s expanded partnership with C4 Therapeutics on next-generation antibody conjugates.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
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<span><span class="js-time" data-epochtime="1776074400" data-format="short_date">Apr 13</span></span>
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</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
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</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8885463-act-brief-governance-vs-execution-in-pharma-modernization-ai-workforce-augmentation-planning"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Governance vs. Execution in Pharma Modernization, AI Workforce Augmentation Planning, and Adaptive Trial Regulatory Shifts
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we examine why expanding governance layers slow digital modernization initiatives, how AI will augment clinical trial roles over the next two years, and how evolving regulatory frameworks are reshaping biopharmaceutical development timelines.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1775815200" data-format="short_date">Apr 10</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
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</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8884922-act-brief-diversity-built-into-trial-design-ai-impact-across-trial-lifecycle-and-companion-dia"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Diversity Built Into Trial Design, AI Impact Across Trial Lifecycle, and Companion Diagnostics Adoption
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore why clinical trial diversity requires protocol redesign from the outset, the highest-impact opportunities for AI across the complete trial lifecycle, and the regulatory and operational barriers slowing companion diagnostic adoption in oncology.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1775728800" data-format="short_date">Apr 09</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
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</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8884435-act-brief-risk-based-monitoring-in-global-trials-patient-centered-ai-design-and-generative-ai"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Risk-Based Monitoring in Global Trials, Patient-Centered AI Design, and Generative AI in Healthcare
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we examine the technical and operational challenges of implementing risk-based monitoring across global trials, how AI must address social determinants of health and site burden, and the emerging role of domain-specific generative AI in clinical practice.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
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<span><span class="js-time" data-epochtime="1775642400" data-format="short_date">Apr 08</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8883921-act-brief-ai-leadership-and-organizational-adoption-bayesian-methods-in-drug-development-and-n"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: AI Leadership and Organizational Adoption, Bayesian Methods in Drug Development, and NIH Budget Reductions
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore the leadership priorities that enable meaningful AI gains in clinical research, how Bayesian methodologies are reshaping trial design and innovation, and proposed federal budget cuts threatening NIH research funding.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1775556000" data-format="short_date">Apr 07</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8882845-act-brief-real-world-data-across-therapeutic-areas-ai-driven-case-intake-and-covid-19-vaccine"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Real-World Data Across Therapeutic Areas, AI-Driven Case Intake, and COVID-19 Vaccine Trial Enrollment Challenges
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we examine how real-world data is being applied across oncology, ophthalmology, and other therapeutic areas to optimize trial design, how AI is reshaping clinical case intake workflows, and enrollment barriers that led Pfizer and BioNTech to halt a COVID-19 vaccine trial.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1775469600" data-format="short_date">Apr 06</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8882414-act-brief-digital-twins-for-virtual-control-arms-clinical-tech-stack-evolution-and-universal-f"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Digital Twins for Virtual Control Arms, Clinical Tech Stack Evolution, and Universal Flu Vaccine Advances
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore how digital twin technology creates reliable virtual control arms from historical data, what defines an effective clinical trial tech stack in complex studies, and emerging vaccine platforms advancing toward universal influenza protection.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1775210400" data-format="short_date">Apr 03</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8881856-act-brief-platform-vs-bespoke-technology-patient-and-site-experience-design-and-ai-driven-adc"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Platform vs. Bespoke Technology, Patient and Site Experience Design, and AI-Driven ADC Development
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore how to decide which trial complexities warrant core technology platforms versus custom configurations, how measuring patient and site experiences early identifies actionable solutions, and Daiichi Sankyo&#39;s collaboration with Tempus to improve ADC patient selection through AI.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
1m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1775124000" data-format="short_date">Apr 02</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
1m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8881290-act-brief-intuitive-technology-design-and-site-compliance-vaccine-follow-up-strategy-optimizati"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Intuitive Technology Design and Site Compliance, Vaccine Follow-Up Strategy Optimization, and AI-Driven Antibody Discovery
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore how user-friendly technology reduces errors and site workarounds, strategic approaches to combining traditional and real-world data collection for vaccine long-term follow-up, and Merck&#39;s collaboration with Infinimmune to accelerate antibody discovery using AI.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1775037600" data-format="short_date">Apr 01</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8880711-act-brief-clinical-technology-implementation-priorities-digital-supply-chain-integration-and-a"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Clinical Technology Implementation Priorities, Digital Supply Chain Integration, and AI Drug Discovery Scale
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we examine the three converging technology priorities reshaping trial execution in 2026, why sponsors must integrate digital and physical supply chains operationally, and Eli Lilly&#39;s multi-billion dollar AI drug discovery collaboration with Insilico.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1774951200" data-format="short_date">Mar 31</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8879861-act-brief-clinical-workflow-user-experience-sample-integrity-and-logistics-and-fda-s-unified-a"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Clinical Workflow User Experience, Sample Integrity and Logistics, and FDA&#39;s Unified Adverse Event System
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we examine why eClinical platforms must prioritize user workflows over data flow, how digitizing sample tracking prevents integrity failures in transit, and the FDA&#39;s consolidated adverse event monitoring system enabling real-time safety signal detection.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1774864800" data-format="short_date">Mar 30</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8879390-act-brief-cro-selection-as-incentive-design-integrated-tech-stack-strategy-and-pricing-disrupt"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: CRO Selection as Incentive Design, Integrated Tech Stack Strategy, and Pricing Disruption in Pharma
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we examine how game theory principles can improve CRO and vendor selection through ecosystem alignment, why clinical technology platforms must be purpose-built and fully integrated, and how pricing pressures and regulatory changes are reshaping pharmaceutical R&amp;D investment.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1774605600" data-format="short_date">Mar 27</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8878815-act-brief-behavioral-science-and-recruitment-design-community-engagement-in-trials-and-big-pha"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Behavioral Science and Recruitment Design, Community Engagement in Trials, and Big Pharma&#39;s Rare Disease Interest
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
: In today&#39;s ACT Brief, we examine how behavioral science applied during trial design and startup can identify recruitment barriers early, the importance of authentic community engagement over traditional outreach, and how large pharmaceutical companies are increasingly investing in rare disease development.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1774519200" data-format="short_date">Mar 26</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8878324-act-brief-thermo-fisher-acquires-clario-wearables-and-ai-integration-and-somatic-genomics-for-ibd"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Thermo Fisher Acquires Clario, Wearables and AI Integration, and Somatic Genomics for IBD
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we examine Thermo Fisher&#39;s acquisition of Clario to expand clinical trial data infrastructure, how wearable devices and AI are reshaping patient monitoring workflows, and a collaboration between Merck and Quotient using somatic genomics to identify IBD drug targets.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1774432800" data-format="short_date">Mar 25</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8877782-act-brief-ai-and-wearables-for-patient-monitoring-fda-modernizes-evidence-standards-and-regula"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: AI and Wearables for Patient Monitoring, FDA Modernizes Evidence Standards, and Regulatory Alignment in Rare Disease
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore how AI can parse wearable data streams to identify subtle clinical patterns, FDA&#39;s four major policy shifts modernizing drug development and approval standards, and ongoing questions about regulatory consistency in rare disease pathways.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1774346400" data-format="short_date">Mar 24</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8876758-act-brief-fda-clearance-and-reimbursement-for-wearables-data-validation-across-complex-trials"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: FDA Clearance and Reimbursement for Wearables, Data Validation Across Complex Trials, and Wegovy HD Approval
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore how FDA clearance and reimbursement models support wearable adoption in clinical care, the importance of end-to-end data validation before patient enrollment, and FDA approval of a higher-dose semaglutide formulation for weight loss.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1774260000" data-format="short_date">Mar 23</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8876289-act-brief-wearable-data-integration-challenges-human-performance-science-and-rare-disease-regu"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Wearable Data Integration Challenges, Human Performance Science, and Rare Disease Regulatory Flexibility
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
 In today&#39;s ACT Brief, we explore the data overload and alert fatigue challenges in integrating wearable data into clinical workflows, how cognitive and behavioral science can transform site readiness and training, and FDA&#39;s evolving guidance on rare disease trial design and evidence standards.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1774000800" data-format="short_date">Mar 20</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8875758-act-brief-remote-monitoring-and-early-intervention-nams-replace-animal-testing-and-glass-box-c"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Remote Monitoring and Early Intervention, NAMs Replace Animal Testing, and Glass Box Clinical Intelligence
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore how continuous remote monitoring enables early clinical interventions, FDA guidance on validating new approach methodologies as alternatives to animal testing, and the importance of transparent data collection in decentralized trials.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1773914400" data-format="short_date">Mar 19</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8875526-act-brief-wearable-data-in-clinical-care-generalized-pairwise-comparisons-and-vaccine-policy-l"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Wearable Data in Clinical Care, Generalized Pairwise Comparisons, and Vaccine Policy Litigation
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore how wearable data is informing real-world clinical decision-making, a statistical method that analyzes multiple patient outcomes simultaneously to improve trial design, and legal challenges to recent vaccine advisory committee changes.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1773843480" data-format="short_date">Mar 18</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8875164-act-brief-academic-trial-infrastructure-vaccine-engagement-strategies-workflow-orchestration"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Academic Trial Infrastructure, Vaccine Engagement Strategies, Workflow Orchestration
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we examine the technology infrastructure gap facing investigator-initiated trials, how transparency and community engagement drive vaccine adoption, and why workflow orchestration—not just digitization—delivers operational value in clinical research.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1773771060" data-format="short_date">Mar 17</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8872759-act-brief-trial-transparency-and-synthetic-controls-readiness-as-leading-risk-indicator-fda-st"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Trial Transparency and Synthetic Controls, Readiness as Leading Risk Indicator, FDA Streamlines Biosimilar Pathway
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore the transparency demands of complex trial designs and synthetic controls, how measuring site readiness during training predicts protocol execution, and the FDA&#39;s streamlined biosimilar development pathway aimed at reducing drug costs.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1773309600" data-format="short_date">Mar 12</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8872219-act-brief-trial-data-transparency-protocol-design-drives-enrollment-fda-shifts-approval-standards"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Trial Data Transparency, Protocol Design Drives Enrollment, FDA Shifts Approval Standards
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we examine why transparency in complex trial designs is essential for data confidence, how protocol structure—not operational effort—determines recruitment success, and the FDA&#39;s shift toward single-trial approvals with enhanced post-market surveillance.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
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<span><span class="js-time" data-epochtime="1773223200" data-format="short_date">Mar 11</span></span>
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</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
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</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
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<a class="text-decoration-none" href="/posts/8871669-act-brief-bayesian-shifts-regulatory-culture-quality-tolerance-limits-drive-risk-management-cb"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Bayesian Shifts Regulatory Culture, Quality Tolerance Limits Drive Risk Management, CBER Leadership Changes
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore how Bayesian methods are reshaping FDA interactions and trial design, quality tolerance limits are becoming operational guardrails in risk-based quality management, and leadership transitions at the FDA&#39;s Center for Biologics Evaluation and Research signal evolving regulatory priorities.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
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<span><span class="js-time" data-epochtime="1773136800" data-format="short_date">Mar 10</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
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2m
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</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8870793-act-brief-bayesian-implementation-women-in-statistics-and-fda-tightens-gene-therapy-standards"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Bayesian Implementation, Women in Statistics, and FDA Tightens Gene Therapy Standards
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore the operational capabilities clinical teams need to implement Bayesian trial designs, why gender diversity strengthens data science across drug development, and the FDA&#39;s rejection of external controls for a Huntington&#39;s gene therapy candidate.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1773050400" data-format="short_date">Mar 09</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
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</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8870284-act-brief-bayesian-methods-drive-adaptive-trials-digital-endpoints-gain-regulatory-footing-and"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Bayesian Methods Drive Adaptive Trials, Digital Endpoints Gain Regulatory Footing, and FDA Cracks Down on Compounded GLP-1 Marketing
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today&#39;s ACT Brief, we explore how Bayesian approaches are powering studies in rare disease and pediatrics, a major public-private initiative is standardizing digital endpoints for regulatory acceptance, and the FDA intensifies enforcement against misleading GLP-1 marketing.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1772794800" data-format="short_date">Mar 06</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8869516-act-brief-bayesian-trials-advance-esource-integration-scales-and-fda-standards-shift"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Bayesian Trials Advance, eSource Integration Scales, and FDA Standards Shift
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we highlight how Bayesian methods are reshaping adaptive trial design, a major eSource partnership is improving data flow and accuracy, and FDA approval standards continue to evolve.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
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</span>
<span><span class="js-time" data-epochtime="1772708400" data-format="short_date">Mar 05</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8869016-act-brief-bayesian-approaches-expand-patient-foundations-merge-and-ai-transforms-clinical-trials"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Bayesian Approaches Expand, Patient Foundations Merge, and AI Transforms Clinical Trials
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we highlight how Bayesian methods are gaining operational traction, a major patient advocacy merger is streamlining clinical trial access, and machine learning is reshaping trial design through multi-modal data integration.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
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</span>
<span><span class="js-time" data-epochtime="1772622000" data-format="short_date">Mar 04</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8868833-act-brief-rwd-integration-accelerates-fda-advances-ultra-rare-therapies-and-collaboration-shap"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: RWD Integration Accelerates, FDA Advances Ultra-Rare Therapies, and Collaboration Shapes the Next Decade
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we examine how the Verana Health-COTA merger is evolving real-world data use, the FDA’s new framework for individualized ultra-rare disease therapies, and what a decade of cross-industry collaboration reveals about the future of clinical development.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1772549493" data-format="short_date">Mar 03</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8868433-rwd-at-scale-how-verana-health-and-cota-are-shaping-the-future-of-clinical-development"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43508123/75x75/c 75w, https://audioboom.com/i/43508123/150x150/c 150w, https://audioboom.com/i/43508123/300x300/c 300w, https://audioboom.com/i/43508123/600x600/c 600w, https://audioboom.com/i/43508123/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #c0c0c0; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43508123/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
RWD at Scale: How Verana Health and COTA Are Shaping the Future of Clinical Development
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In this episode of the Applied Clinical Trials Podcast, C.K. Wang, MD, chief medical officer at COTA; and Sujay Jadhav, CEO of Verana Health, discuss how their organizations’ merger is advancing the use of real-world data to inform trial design, patient recruitment, and regulatory decision-making.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
21m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1772479778" data-format="short_date">Mar 02</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
21m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8867428-act-brief-bayesian-designs-gain-ground-data-priorities-take-shape-and-rare-disease-strategy-ex"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Bayesian Designs Gain Ground, Data Priorities Take Shape, and Rare Disease Strategy Expands
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we explore how Bayesian trial designs are gaining traction in rare disease research, what priorities clinical operations leaders should focus on in 2026, and how rare disease science is shaping broader drug development strategies.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1772449200" data-format="short_date">Mar 02</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8866630-act-brief-sites-advance-ai-adoption-cross-functional-alignment-moves-earlier-and-phase-i-strat"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Sites Advance AI Adoption, Cross-Functional Alignment Moves Earlier, and Phase I Strategy Evolves
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we explore how sites are taking the lead on AI adoption to strengthen feasibility and enrollment, why earlier cross-functional alignment is critical in data-driven trials, and how Phase I strategy is shifting toward quantitative evidence generation.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1772190000" data-format="short_date">Feb 27</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8866270-act-brief-data-fragmentation-risks-rise-outsourcing-models-evolve-and-fda-pathways-face-pressure"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Data Fragmentation Risks Rise, Outsourcing Models Evolve, and FDA Pathways Face Pressure
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we examine how fragmented data collection continues to challenge trial quality, how hybrid outsourcing and AI are reshaping execution strategies, and why calls are growing for a risk-based FDA pathway for early-stage studies.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1772103600" data-format="short_date">Feb 26</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
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</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8865577-act-brief-esource-standardization-advances-digital-protocols-gain-momentum-and-rare-disease-tr"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: eSource Standardization Advances, Digital Protocols Gain Momentum, and Rare Disease Trial Risks Intensify
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we examine how protocol-driven eSource is reshaping data capture at sites, how digital protocols and data sharing are redefining trial execution, and how a Duchenne study termination highlights growing operational risks in rare disease development.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1772017200" data-format="short_date">Feb 25</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8864978-act-brief-site-data-quality-takes-priority-merck-expands-ai-discovery-efforts-and-gilead-advan"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Site Data Quality Takes Priority, Merck Expands AI Discovery Efforts, and Gilead Advances Cell Therapy Strategy
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we examine how site-level data capture is becoming central to trial execution, how Merck and Mayo Clinic are scaling AI-driven discovery, and how Gilead’s latest acquisition strengthens its position in cell therapy for multiple myeloma.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1771930800" data-format="short_date">Feb 24</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8864785-act-brief-evinova-expands-ai-partnerships-ctpm-role-evolves-and-fda-pressure-builds-on-glp-1-m"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Evinova Expands AI Partnerships, CTPM Role Evolves, and FDA Pressure Builds on GLP-1 Market
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we examine how Evinova is scaling AI-driven clinical development through industry collaboration, how the clinical trial project manager role is evolving amid growing complexity, and how FDA scrutiny of compounded GLP-1s could reshape market dynamics.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1771864184" data-format="short_date">Feb 23</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8863455-act-brief-scope-highlights-operational-discipline-ai-adoption-accelerates-execution-and-fda-re"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: SCOPE Highlights Operational Discipline, AI Adoption Accelerates Execution, and FDA Rethinks Evidence Standards
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we examine how SCOPE 2026 reinforced the link between speed and strategy, how AI adoption is driving real-world efficiency gains, and how FDA’s evolving evidence standards could reshape approval pathways.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1771585200" data-format="short_date">Feb 20</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8862957-act-brief-predictive-analytics-advance-collaborative-data-standards-scale-and-moderna-s-flu-va"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Predictive Analytics Advance, Collaborative Data Standards Scale, and Moderna’s Flu Vaccine Review Moves Forward
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we examine how predictive analytics are shaping portfolio decisions, how industry collaboration is scaling digital data standards, and how FDA review of an mRNA flu vaccine candidate is back on track.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1771498800" data-format="short_date">Feb 19</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8862408-act-brief-ai-enables-real-time-trial-oversight-provider-engagement-strengthens-recruitment-and"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: AI Enables Real-Time Trial Oversight, Provider Engagement Strengthens Recruitment, and HHS Leadership Restructures Operations
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we examine how AI is enabling continuous trial monitoring and faster site decisions, how provider participation influences recruitment in pragmatic trials, and how leadership restructuring at HHS may shape health policy execution.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1771412400" data-format="short_date">Feb 18</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8861952-act-brief-ai-moves-into-implementation-digital-measurement-adoption-accelerates-and-global-tri"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: AI Moves Into Implementation, Digital Measurement Adoption Accelerates, and Global Trial Competition Intensifies
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we examine how AI is shifting from pilot programs into daily development workflows, how a new adoption platform is helping sponsors integrate digital measurement tools, and how global competition and data-driven site selection are reshaping clinical trial activity.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1771326000" data-format="short_date">Feb 17</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8861785-act-brief-esource-moves-toward-ai-enabled-validation-outsourcing-models-shift-toward-flexibilit"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: eSource Moves Toward AI-Enabled Validation, Outsourcing Models Shift Toward Flexibility, and Robust Trial Design Becomes Mission Critical
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we explore how eSource adoption is advancing with AI-enabled validation and interoperability, examine how flexible outsourcing models are helping sponsors balance control and efficiency, and highlight why adaptive, simulation-driven trial design is becoming essential to improving study success.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1771251946" data-format="short_date">Feb 16</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8860954-act-brief-regional-risk-variability-emerges-patient-experience-drives-retention-and-digital-en"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Regional Risk Variability Emerges, Patient Experience Drives Retention, and Digital Endpoints Scale in Oncology
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we examine new data on regional variation in clinical trial risk, why patient experience must move from intent to execution, and how digital endpoints are advancing efficiency and regulatory alignment in oncology trials.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1770992467" data-format="short_date">Feb 13</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8860443-act-brief-real-world-data-connectivity-expands-ai-supports-smarter-data-capture-and-diversity"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Real-World Data Connectivity Expands, AI Supports Smarter Data Capture, and Diversity Strategies Refocus at SCOPE
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we cover a new real-world data collaboration aimed at scalable interoperability, how AI fits into modern data capture and quality oversight, and what leaders say must change to move diversity efforts forward in clinical trials.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1770906510" data-format="short_date">Feb 12</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8859633-act-brief-ai-scales-trial-design-esg-becomes-a-readiness-test-and-sites-push-back-on-payment-p"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: AI Scales Trial Design, ESG Becomes a Readiness Test, and Sites Push Back on Payment Practices
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we cover how AI is being deployed to optimize global trial design, why ESG performance is emerging as a core vendor qualification signal, and how sites are becoming more selective as payment practices come under scrutiny.
</div>
<div class="text-muted df align-items-baseline gap-2 fs-8">
<span class="numeric-tabular d-sm-none">
2m
</span>
<span class="d-sm-none">
&bull;
</span>
<span><span class="js-time" data-epochtime="1770807600" data-format="short_date">Feb 11</span></span>
</div>
</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
<div class="fs-8 numeric-tabular text-nowrap text-muted phs">
2m
</div>
</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
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<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Purpose Meets Operational Focus, Acceleration Shifts Upstream, and AI Delivers Near-Term Impact
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we highlight how purpose-driven efficiency is reshaping clinical development priorities, where leaders see the greatest opportunity for accelerating trial timelines, and how artificial intelligence is already influencing decisions across the R&amp;D lifecycle.
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<span class="numeric-tabular d-sm-none">
2m
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<span><span class="js-time" data-epochtime="1770721200" data-format="short_date">Feb 10</span></span>
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2m
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</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8854362-act-brief-fda-capacity-strains-timelines-sponsors-rethink-site-support-and-regulators-align-on-ai"><div class="Episode-list-grid card-body pan">
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<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: FDA Capacity Strains Timelines, Sponsors Rethink Site Support, and Regulators Align on AI
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we examine how reduced FDA capacity is extending regulatory timelines, why sponsors are rethinking operating models to reduce site burden in 2026, and how the FDA and EMA are aligning around guiding principles for artificial intelligence in drug development.
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2m
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<span><span class="js-time" data-epochtime="1769770800" data-format="short_date">Jan 30</span></span>
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</div>
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<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
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2m
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</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8854189-act-brief-rwe-refines-trial-design-oncology-cro-scale-expands-and-feasibility-pressures-persist"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: RWE Refines Trial Design, Oncology CRO Scale Expands, and Feasibility Pressures Persist
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we look at how real-world evidence is reshaping trial design rather than replacing trials, what Worldwide Clinical Trials’ acquisition of Catalyst Clinical Research signals for oncology-focused CRO models, and new data showing feasibility and enrollment challenges remain stubborn across global trials.
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<span><span class="js-time" data-epochtime="1769697851" data-format="short_date">Jan 29</span></span>
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<a class="text-decoration-none" href="/posts/8850689-act-brief-esg-moves-into-vendor-oversight-rwe-faces-governance-hurdles-and-roche-advances-obes"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: ESG Moves Into Vendor Oversight, RWE Faces Governance Hurdles, and Roche Advances Obesity Pipeline
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we examine why ESG efforts in clinical development are shifting into vendor oversight, what data and governance barriers still limit broader use of de-identified RWE in submissions, and new Phase II obesity data from Roche as its program moves toward Phase III.
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<span><span class="js-time" data-epochtime="1769598000" data-format="short_date">Jan 28</span></span>
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<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
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2m
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</div>
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</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8846115-act-brief-decentralized-innovation-faces-reality-rwe-finds-its-lane-and-clinical-ops-reset-for"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: Decentralized Innovation Faces Reality, RWE Finds Its Lane, and Clinical Ops Reset for 2026
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we explore why decentralized trial innovations struggle to scale without better change management, where real-world evidence most realistically complements traditional trials, and how efficiency, AI, and platformization are expected to reshape clinical operations in 2026.
</div>
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2m
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<span><span class="js-time" data-epochtime="1769511600" data-format="short_date">Jan 27</span></span>
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</div>
</div>
<div class="d-none d-sm-grid" style="justify-self: center; align-items: center;">
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2m
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</div>
</div>
</a></div>
<hr class="mvn mhs text-black-50 opacity-25">
<div class="card rounded-0 border-0 pas qa-audio-clip-overview" style="--bs-card-bg: transparent;">
<a class="text-decoration-none" href="/posts/8844278-act-brief-de-identified-data-expands-trial-design-global-production-normalizes-and-fda-updates"><div class="Episode-list-grid card-body pan">
<div class="l-flex align-items-baseline gap-2 gap-md-3">
<img srcset="https://audioboom.com/i/43391979/75x75/c 75w, https://audioboom.com/i/43391979/150x150/c 150w, https://audioboom.com/i/43391979/300x300/c 300w, https://audioboom.com/i/43391979/600x600/c 600w, https://audioboom.com/i/43391979/1400x1400/c 1400w" sizes="(max-width: 400px) 64px, 96px" style="background-color: #f3f3f3; max-width: 96px; width: 15cqw;" class="js-img-bg ratio-square rounded-1" loading="lazy" src="https://audioboom.com/i/43391979/1400x1400/c" />
<div class="vstack gap-1 my-auto">
<h5 class="text-line-clamp text-line-clamp-3 balanced-h fs-6 fs-5-lg fw-normal mb-0">
ACT Brief: De-Identified Data Expands Trial Design, Global Production Normalizes, and FDA Updates Quality Framework
</h5>
<div class="text-line-clamp text-line-clamp-3 balanced-p fs-8 text-muted text-break">
In today’s ACT Brief, we examine how large de-identified datasets are reshaping trial design and site strategy, why global pharmaceutical production is expected to cool after a tariff-driven surge, and what FDA’s new M4Q(R2) draft guidance means for quality submissions.
</div>
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2m
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<span><span class="js-time" data-epochtime="1769425200" data-format="short_date">Jan 26</span></span>
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</div>
</div>
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2m
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