{"type":"rich","version":"1.0","title":"Cancer Vaccines: The Future is Now","description":"As cancer vaccines move into Phase II and III clinical trials, it is\nincreasingly important for surgeons to understand their role in this\nevolving landscape. What exactly are these vaccines, how do they work,\nand what should the surgical community know about their\nimplementation? Join BTK surgical education fellows Kara Button and\nMichelle LaBella as they sit down with Professor Robert Jones to break\ndown the science of mRNA vaccines, the logistics of tissue\nprocurement, and the future of cancer care.\n\nHosts:\n\n- Professor Robert Jones: Consultant Liver Surgeon, Liverpool University\nHospitals; UK National Institute for Healthcare Research, Co-Lead for\nthe Cancer Vaccine Innovation Pathway, Bowel Cancer UK and Royal\nCollege of Surgeons UK Lead for Research into Advanced Bowel Cancer,\nand UK Chief Investigator for the BNT122-01 trial.\nhttps://www.linkedin.com/in/robert-jones-6103722a/\n\n- Kara Button, DO: General Surgery Resident, Maine Medical Center;\nBehind the Knife Surgical Education Fellow.\n\n- Michelle LaBella, MD: General Surgery Resident; University of North\nCarolina; Behind the Knife Surgical Education Fellow.\n\nReferences:\n\nhttps://clinicaltrials.biontech.com/trials/BNT122-01\n\nJones RP, Lee LYW, Corrie PG, et al. Individualized cancer vaccines\nversus surveillance after adjuvant chemotherapy for surgically\nresected high-risk stage 2 and stage 3 colorectal cancer: protocol for\na randomized trial. BJS. 2023;110(12):1883-1884.\ndoi:10.1093/bjs/znad332\nhttps://pubmed.ncbi.nlm.nih.gov/37856683/\n\nTie J, Wang Y, Loree JM, et al. Circulating tumor DNA-guided adjuvant\ntherapy in locally advanced colon cancer: the randomized phase 2/3\nDYNAMIC-III trial. Nat Med. 2025;31(12):4291-4300.\ndoi:10.1038/s41591-025-04030-w\nhttps://pubmed.ncbi.nlm.nih.gov/41115959/\n\nRojas LA, Sethna Z, Soares KC, et al. Personalized RNA neoantigen\nvaccines stimulate T cells in pancreatic cancer. Nature.\n2023;618(7963):144-150. doi:10.1038/s41586-023-06063-y\nhttps://pubmed.ncbi.nlm.nih.gov/37165196/\n\nhttps://www.cancer.ox.ac.uk/research/lynchvax#:~:text=The%20LynchVax%20program%2C%20funded%20by,individuals%20with%20this%20genetic%20condition\n\nPlease visit https://behindtheknife.org (https://behindtheknife.org/) to access other high-yield surgical education podcasts, videos and more.\nIf you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen\nBehind the Knife Premium: https://behindtheknife.org/premium\nOral Board Review:https://behindtheknife.org/oral-board\nOral Board Simulator: https://behindtheknife.org/oral-board/simulator\nGeneral Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review\nTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas\nDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship\nDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation\nVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review\nColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review\nSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review\nCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review\nDownload our App:\nApple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049\nAndroid/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US","author_name":"Behind The Knife: The Surgery Podcast","author_url":"https://audioboom.com/channels/5046960-behind-the-knife-the-surgery-podcast","provider_name":"Audioboom","provider_url":"https://audioboom.com","width":480,"height":95,"thumbnail_url":"https://audioboom.com/i/39463562/600x600/c","thumbnail_width":600,"thumbnail_height":600,"html":""}