rich 1.0 Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this Mind Moments episode, Jennifer Fokas, MD, and Minali Nigam, MD, neurologists at Northwestern Medicine with specialized training in headache medicine, join the podcast to discuss current challenges and evolving strategies in the management of cluster headache. They highlighted the substantial burden of disease, particularly among patients with chronic cluster headache, and the diagnostic difficulties that arise from overlap with migraine features. They emphasized the importance of recognizing cranial autonomic symptoms as key distinguishing features, along with typical attack duration and circadian or seasonal patterns. The conversation also covered practical approaches to acute and preventive treatment, including high-flow oxygen via non-rebreather mask, subcutaneous sumatriptan, bridge therapies, and preventive options such as high-dose verapamil and, in selected cases, lithium. The physicians also review emerging and adjunctive options while noting limitations in evidence, indications, and access. They concluded by underscoring the need for clinician preparedness and tailored therapy to enable more assertive and appropriate management of cluster headache. Looking for more Headache and Migraine discussion? Check out the NeurologyLive® Headache and Migraine focus page (https://www.neurologylive.com/clinical/headache-migraine) . Episode Breakdown: 1:54 – Biggest unmet need in cluster headache 5:01 – Importance of multimodal acute management and access issues 7:39 – Neurology News Minute 10:03 – Emerging and experimental therapies 13:03– Preventive options and special situations 17:51 – Key clinical takeaway: preparation and access to therapies The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: FDA Approves Zilganersen, First Treatment for Alexander Disease (https://www.neurologylive.com/view/fda-approves-zilganersen-first-treatment-alexander-disease) FDA Priority Review Puts Satralizumab on Track as First MOGAD Drug (https://www.neurologylive.com/view/fda-priority-review-puts-satralizumab-track-first-mogad-drug) FDA Approves Apitegromab for Spinal Muscular Atrophy (https://www.neurologylive.com/view/fda-approves-apitegromab-spinal-muscular-atrophy) Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com (http://neurologylive.com/) . REFERENCE 1. Burish MJ, Pearson SM, Shapiro RE, Zhang W, Schor LI. Cluster headache is one of the most intensely painful human conditions: Results from the International Cluster Headache Questionnaire. Headache. 2021;61(1):117-124. doi:10.1111/head.14021 NeurologyLive® Mind Moments® https://audioboom.com/channels/5001429-neurologylive-mind-moments Audioboom https://audioboom.com 480 95 https://audioboom.com/i/39490422/600x600/c 600 600 <iframe width="100%" height="95" src="https://embeds.audioboom.com/posts/8953987/embed?v=202301" style="background-color: transparent; display: block; padding: 0; width: 100%" frameborder="0" allowtransparency="allowtransparency" scrolling="no" title="Audioboom player" allow="autoplay" sandbox="allow-downloads allow-forms allow-popups allow-same-origin allow-scripts allow-storage-access-by-user-activation allow-top-navigation-by-user-activation"></iframe>