HIV Remission, Bones, Jumping Spiders. March 8, 2019, Part 2

Nearly twelve years ago, a cancer patient infected with HIV received two bone marrow transplants to wipe out his leukemia. Now, researchers in the United Kingdom reported in Nature earlier this week that their patient, a man known only as “the London patient,” had been in remission and off anti-retroviral therapy for 18 months after undergoing a similar bone marrow transplant, with the same gene mutation involved, to treat leukemia. While the team is hesitant to call their patient cured, he is the first adult in twelve years to remain in remission for more than a year after stopping medication. But what do these two patients’ recoveries, requiring risky and painful transplants, mean for the millions of others with HIV around the world? Two HIV researchers not involved in this research, Katharine Bar of the University of Pennsylvania and Paula Cannon of the University of Southern California, tell us about the latest treatments that could someday be more broadly accessible, including gene therapies and immunotherapy, and what hurdles clinical studies still face.

Plus: Over 500 million years of evolution has resulted in the same bony framework underlying all mammal species today. But why is the leg bone connected to the ankle bone, as the song goes? And what can the skeletons of our ancestors tell us about how humans became the walking, talking bag o’ bones we are today? Science writer Brian Switek, author of the new book Skeleton Keys, joins Ira to explain why our skeletons evolved to look the way they do.

And jumping spiders are crafty hunters, but sometimes they need their own disguise to avoid their own predators. The Crematogaster jumping spider, for example, avoids detection by mimicking ants, and go as far as losing their ability to jump to look more ant-like. Sometimes, predators can be your own mates—male jumping spiders becoming a female’s meal if their courtship displays don’t impress. Biologist Alexis Dodson and  Entomologist Lisa Taylor talk about what jumping spiders can tell us about tell us about the evolution of coloration and communication in the natural world.