Journal Review in Colorectal Surgery: Total Neoadjuvant Therapy (TNT) for Rectal Cancer

Adjuvant?  Neoadjuvant?  Short course?  Long course?  The treatment of rectal cancer treatment has come a long way.  Tune in to learn more about Total Neoadjuvant Therapy (TNT) and the mysterious HOLY PLANE.

Learning Objectives:

1.    Describe the rationale for Total Neoadjuvant Therapy (TNT) for rectal cancer
2.    Review the history of chemo and radiation therapy in treatment of rectal cancer
3.    Describe total mesorectal excision 

References

Bahadoer RR, Dijkstra EA, van Etten B et al. Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial. Lancet Oncol. 2021 Jan;22(1):29-42. doi: 10.1016/S1470-2045(20)30555-6. Epub 2020 Dec 7
https://doi.org/10.1016/S1470-2045(20)30555-6

Fokas E, Allgäuer M, Polat B et al. Randomized Phase II Trial of Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: CAO/ARO/AIO-12. J Clin Oncol. 2019 Dec 1;37(34):3212-3222. doi: 10.1200/JCO.19.00308
https://ascopubs.org/doi/10.1200/JCO.19.00308

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