Coffindaffer: The DNA in the Guthrie Case May Already Be Compromised

Retired FBI Special Agent Jennifer Coffindaffer joins Hidden Killers to assess the forensic evidence in the Nancy Guthrie disappearance — and the picture is complicated. DNA inside the home is a mixture still being separated. A glove found miles away hit nothing in CODIS and doesn't match the property samples. Genetic genealogy is now in play, but requires a usable profile that investigators may not yet have.

Coffindaffer evaluates whether the glove should even be treated as connected to this case, what it takes to separate mixed DNA from a home with regular visitors, and whether the private Florida lab processing the evidence has compromised the material that genetic genealogy needs to work. Othram — the company that helped identify Bryan Kohberger — publicly called the lab decision devastating. Coffindaffer gives her assessment of the competing arguments.

The conversation covers the loss of potential Nest camera footage after Google indicated it likely cannot recover additional video, the ongoing pacemaker helicopter search nineteen days after the device disconnected, and the reality behind 50,000 tips that have produced no named suspect. Coffindaffer identifies the forensic avenues worth pursuing and the ones that should be abandoned.

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This publication contains commentary and opinion based on publicly available information. All individuals are presumed innocent until proven guilty in a court of law. Nothing published here should be taken as a statement of fact, health or legal advice.

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