Diving Into the Safety and Efficacy of Icotrokinra, the New Oral IL-23 Peptide in Psoriasis

Join Dermatology Times for a conversation with Liza O'Dowd, MD, vice president of immunodermatology and respiratory disease areas at Johnson & Johnson, recorded at the 2026 AAD Annual Meeting. Dr. O'Dowd discusses one-year efficacy and safety data for icotrokinra (Icotyde), the newly approved once-daily oral peptide IL-23 receptor antagonist for moderate to severe plaque psoriasis in adults and adolescents 12 and older.

At 52 weeks, approximately 50% of adult patients achieved total skin clearance, rising to 60% in adolescents enrolled in the LEAD study. Adverse event rates through one year remained within 1.1% of placebo, with no mandatory tuberculosis pre-screening required. Dr. O'Dowd also addresses icotrokinra's anticipated role as a first-line systemic therapy and offers practical reassurance for clinicians considering this novel agent for their patients.

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