Understanding BRCA: Naomi’s 80% cancer risk
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Naomi shares how she discovered she carries the BRCA2 gene mutation and has an 80% lifetime risk of breast cancer. We explore genetic testing, risk-reducing surgery, and what it means to live with inherited cancer risk, with expert insight from Jnetics, Jewish genetic disorders charity.
In this episode of the Breast Cancer Now podcast, we explore the role of genetics in cancer risk, including BRCA1 and BRCA2 gene mutations, specifically in Jewish populations.
Naomi shares her powerful story after discovering she carries the BRCA2 gene mutation following the loss of her mum to ovarian cancer. With an 80% lifetime risk of breast cancer, She faced life-changing decisions, and opted for risk-reducing surgery.
Naomi speaks about what it’s like to live with that knowledge, how it shaped her choices, and why taking preventative action gave her a sense of control. She also shares the impact of her gene mutation on her children, and how they've dealt with it as a family.
We’re also joined by Josh from Jnetics, a Jewish genetic disorders charity, who explains the science behind BRCA gene mutations, why they increase cancer risk, and why they are more common in people with Jewish ancestry. He also outlines how testing works, who may be eligible, and what support is available.
Breast Cancer Now
Website: https://breastcancernow.org
Free helpline: 0808 800 6000
Jewish BRCA Testing Programme (NHS England)
Register interest: https://www.jewishbrca.org
Helpline: 020 3437 6001
Jnetics
https://www.jnetics.org
Chai Cancer Care
https://www.chaicancercare.org
You can also watch this episode on YouTube.
Key topics:
1:29 Getting to know Naomi and Josh
4:00 A history of cancer in Naomi's family
7:50 Naomi is tested for the BRCA gene mutation
9:35 What is a genetic mutation or gault?
12:20 Why is the BRCA gene mutation more common in Jewish populations?
17:24 What is BRCA, how does it work, and why does it break?
20:38 Naomi's increased risk of cancer
23:32 Naomi makes the choice to have risk-reducing surgery
27:01 The psychological impact of risk-reducing surgery
28:34 Support for carriers of gene mutations
31:53 How to get tested for BRCA gene mutations
35:52 Coping with the fear of having genetic testing
37:52 Naomi decides how to deal with her daughters potentially being BRCA carriers
39:47 Dealing with feelings of guilt passing on a genetic mutation to a child
41:15 Preventing gene mutations with IVF
42:20 Research into fixing faulty genes
44:06 Cultural barriers to genetic testing within Jewish populations
46:51 Hope for the future of genetic mutations
50:08 More information for people with Jewish heritage
BRCA gene, BRCA2, breast cancer risk, genetic testing UK, hereditary cancer, ovarian cancer risk, mastectomy prevention, cancer genetics, Jewish BRCA, NHS genetic testing, breast cancer awareness UK