How Chronic Stress Rewires the Amygdala, Hippocampus, Prefrontal Cortex and BNST Over Time

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Chronic stress and unresolved trauma don’t just “affect” the brain — they physically reshape it. The amygdala becomes hyper‑reactive and enlarged, priming the body to scan for danger even in safe environments. The hippocampus, responsible for memory and learning, shrinks under long‑term cortisol exposure, making it harder to store new memories and easier to relive old ones as if they’re happening now. The prefrontal cortex — our centre for logic, planning, emotional regulation and decision‑making — goes offline when stress is high, which is why people feel impulsive, overwhelmed, foggy, or unable to “think straight.” And the BNST (bed nucleus of the stria terminalis), the region responsible for sustained anxiety and anticipatory fear, becomes overactive when emotions are suppressed or avoided. Together, these changes create a brain that is wired for survival rather than connection, creativity, or calm.

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