On this episode of The Tell-Tale Heart, Craig Beavers, PharmD, reviews the 2026 American College of Cardiology expert consensus decision pathway on managing heart failure with preserved ejection fraction (HFpEF), recently published in the Journal of the American College of Cardiology. The document moves diagnosis beyond a simple ejection fraction cutoff, emphasizing phenotyping tools such as the H2FPEF score and HFA-PEFF algorithm alongside recognition of HFpEF as a cardiometabolic syndrome tied to obesity, hypertension, diabetes, and chronic kidney disease.

Management of Heart Failure With Preserved Ejection Fraction: 2026 ACC Expert Consensus Decision Pathway: A Report of the American College of Cardiology Solution Set Oversight Committee