Don't Miss a Beat

This episode of Don’t Miss a Beat centers on the evolving treatment landscape for transthyretin amyloid cardiomyopathy (ATTR-CM) with special guest Ahmad Masri, MD. Hosts Muthiah Vaduganathan, MD, MPH, a cardiologist and codirector of the Center for Cardiometabolic Implementation Science at Brigham and Women’s Hospital, and Steve Greene, MD, an advanced heart failure specialist at Duke Universi...

This episode of Don’t Miss a Beat (https://www.hcplive.com/podcasts/dont-miss-a-beat) , recorded at the American College of Cardiology (ACC) 2025 Annual Scientific Sessions (https://www.hcplive.com/conference/acc) , explores the evolving landscape of heart failure (https://www.hcplive.com/clinical/heart-failure) with preserved ejection fraction (HFpEF) treatment, focusing on the implementation ...

In this on-site episode of Don't Miss a Beat from the American College of Cardiology (ACC) 2025 Annual Scientific Sessions (https://www.hcplive.com/conference/acc) , hosts Muthiah Vaduganathan, MD, MPH, and Steve Greene, MD, break down a pair of trials from the meeting: STRIDE and SOUL. STRIDE Trial The STRIDE trial, funded by Novo Nordisk, was a double-blind, randomized, placebo-controlled st...

In this episode of Don't Miss a Beat, hosts Muthiah Vaduganathan, MD, MPH, and Steve Greene, MD, are joined by Taher Modarressi, MD, to explore the practicalities of implementing cardiometabolic therapies in clinical practice. Modarressi shares his experiences establishing a cardiometabolic clinic and offers invaluable advice on overcoming barriers like insurance coverage and cost issues. The d...

Live from ESC Congress 2024! In this edition of Don’t Miss a Beat, Stephen Greene, MD, an advanced heart failure specialist at Duke University School of Medicine, discusses the prospect of finerenone in treatment algorithms for heart failure with Muthiah Vaduganathan, MD, MPH, codirector of the Center for Cardiometabolic Implementation Science of Brigham and Women’s Hospital, based on data fro...

Brendon Neuen, MBBS, PhD, joins hosts to discuss the landmark FLOW trial and its implications on the future of chronic kidney disease management as well as other compelling data surrounding semaglutide from the 61st European Renal Association Congress. Key Highlights: 00:00 - Intro 01:12 - ERA Recap 03:06 - FLOW Background 05:20 - FLOW Results 06:56 - FLOW Reaction (Neuen) 09:13 - Semaglutide ...

In this episode of Don’t Miss a Beat, Javed Butler, MD, joins hosts Muthiah Vaduganthan, MD, MPH, and Steve Greene, MD, for a breakdown of the EMPACT-MI trial, including primary results, secondary findings, how data from DAPA-MI and EMPACT-MI complement each other, and what is next for the SGLT2 inhibitor class. Key Highlights: 00:00 - Intro 01:57 - Trial Design and Results 07:00 - Inclusion...

In this episode, hosts sit down between sessions at AHA 2023 to discuss the landmark SELECT trial, their interpretation of the data, and its implications for care moving forward. Later in the episode, hosts give an overview of the DAPA-MI trial.

On the floor from HFSA 2023! Hosts Muthiah Vaduganathan, MD, MPH, and Steve Greene, MD, are joined by Marat Fudim, MD, MHS, of Duke, to discuss the REBALANCE-HF trial, which examined endovascular ablation of the right greater splanchnic nerve in heart failure with preserved ejection fraction

In this episode of Don't Miss a Beat, hosts offer a breakdown of 3 trials of note from the upcoming ESC Congress 2023 and provide context around the recent announcement of topline results from the SELECT trial.

In this episode of Don’t Miss a Beat, hosts sit down at ESC HFA to discuss key takeaways from the ACC's expert clinical decision pathway and preview HFpEF data scheduled to be presented during the meeting.

Hosts are joined by Tor Biering-Sørenson, MD, MSc, MPH, PhD, to discuss the NUDGE FLU trial and how the lessons learned can inform implementation strategies for various other types of therapies.

Don't Miss a Beat hosts are joined by Alexandre Mebazaa, MD, PhD, lead investigator of the STRONG-HF trial, to discuss the inspiration for the trial, its design, and important takeaways for those looking to implement a similar strategy of rapid, in-hospital uptitration of GDMT in heart failure at their own practice. Video Version (https://www.hcplive.com/view/dont-miss-a-beat-strong-hf-with-al...

Muthiah Vaduganathan, MD, MPH, of Brigham and Women’s Hospital, and Stephen Greene, MD, of the Duke University School of Medicine, are bringing you insights from the floor at the American Heart Association 2022 Scientific Sessions in Chicago, Il. In the episode, which was recorded on day 2 of the 3-day meeting, our hosts offer listeners perspective on the EMPA-KIDNEY and the TRANSFORM-HF trial,...

In this special edition episode of Don’t Miss a Beat, which was filmed on-site at the HFSA 2022 annual scientific meeting, hosts Muthiah Vaduganathan, MD, MPH, codirector of Center for Cardiometabolic Implementation Science at Brigham and Women's Hospital, and Stephen Greene, MD, assistant professor of medicine at Duke University School of Medicine, take the audience on a deep dive into impleme...

In this episode of Don’t Miss a Beat, hosts Stephen Greene, MD, and Muthiah Vaduganathan, MD, MPH, provide a recap of the European Society of Cardiology Congress 2022. This recap begins with a discussion on the results of the phase 3 DELIVER trial, in which Vaduganathan served as an investigator, the ADVOR trial, and REVIVED.

In the latest edition of Don’t Miss a Beat, Drs. Greene and Vaduganathan are joined by special guest Brendon Neuen, MBBS, MSc, of the George Institute of Global Health. A trialist currently contributing to the FIND-CKD trial, Neuen takes Vaduganathan and Greene on a deep dive into the use of eGFR slope as an end point in clinical trials and as a tool in clinical practice. 

A first-in-class allosteric and reversible inhibitor selective for cardiac myosin approved based on the results of the EXPLORER-HCM trial, mavacamten was approved for the treatment of adults with symptomatic NYHA class 2-3 obstructive HCM after their phase 3 data indicated use was with improved exercise capacity, LVOT obstruction, NYHA functional class, and health status patients with oHCM. I...

In this episode of Don't Miss a Beat, hosts Drs. Greene and Vaduganathan break down the new ACC/AHA/HFSA heart failure guidelines debuted at ACC.22 and compare the recommendations against those made in the European Society of Cardiology's 2021 heart failure guidelines.

Headed to ACC.22 this weekend or following along virtually? Get the weekend started with our special ACC.22 preview edition of Don't Miss a Beat. Hear from co-hosts Drs. Vaduganathan and Greene on their top picks from the late-breaking sessions at the upcoming American College of Cardiology meeting and offer their thoughts on the recent EMPA-KIDNEY announcement. 

Dr. Eugene Braunwald joins Don't Miss a Beat hosts Dr. Greene and Dr. Vaduganathan to provide perspective on founding the TIMI study group, how trials have evolved, and advice he would give to young professionals interested in becoming trialists.

Join Dr. Steve Greene and Dr. Muthiah Vaduganathan for a regular news roundup of the latest evidence and clinical trial insights across cardiovascular, renal, and metabolic diseases. In the inaugural episode of Don't Miss a Beat, Drs. Greene and Vaduganathan discuss the impact of an early career mentor and provide insight into their favorite trials from 2021, including EMPEROR-Preserved and SS...

Based on a study she presented at ACC.21, Laxmi Mehta, MD, discusses COVID-19 and burnout among cardiology professionals with Practical Cardiology senior editor Patrick Campbell.  This conversation has been edited for time and clarity.

In this episode, Dr. Stephen Greene, of the Duke Clinical Research Institute, breaks down a recent study he led comparing the sensitivity of NYHA class versus patient-reported outcomes for capturing changes in disease state among patients with HFrEF.

In this special National Wear Red Day edition of Inside Cardiology, we speak with Jennifer Majersik, MD, about a special edition of the Stroke journal highlighting disparities in stroke care for women. 

Prof. Kausik Ray discusses inclisiran data from the ORION program presented at ESC Congress 2020 and examines whether clinicians should feel comfortable prescribing the agents based on clinical trial data.

This episode features Robert L. Page II, PharmD, a professor of clinical pharmacy at the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences and co-author of a recent scientific statement from the American Heart Association (AHA) describing the current state of understanding regarding marijuana and its effect on cardiovascular health.  

For this episode, you will be hearing from Dr. Deepak Bhatt. Dr. Bhatt is the lead author of a recent article published in the Journal of the American Heart Association examining the impact of the ongoing COVID-19 pandemic.  A leading trialist, Dr. Bhatt offers perspective on data and from personal experience on how the pandemic has, is, and will continue to effect clinical trials, with the ri...

Hear fromDr. Hyung Chun, associate professor of medicine and pathology at Yale School of Medicine and director of Translational Research in the Yale Pulmonary Vascular Disease Program.  Dr. Chun recently led a study examining one of the most pressing issues in the treatment of COVID-19 patients: Blood clots. In the interview, we discuss the potential mechanism behind blood clots in COVID-19 pa...